Vision 20/20: Mammographic breast density and its clinical applications

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Imperfect correlation of mammographic and clinical breast tissue density.

BACKGROUND Clinicians determine degree of mammographic density based on tissue firmness on breast examination. The study aimed to compare breast density in mammography and clinical breast examination. MATERIALS AND METHODS Six-hundred sixty three women 40 years of age or older were studied. The breast exam density was graded from 1 to 4 by two expert surgeons and the mammographic parenchymal ...

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Mammographic breast density, endocrine therapies, and breast cancer risk

MBD and breast cancer risk Elevated MBD is considered one of the strongest risk factors for breast cancer regardless of whether it is assessed as a categorical or quantitative measure.6 Women in the highest categories of breast density have a 4to 6-fold increased breast cancer risk compared with women in the lowest categories. MBD has been shown to be a stronger risk factor for breast cancer th...

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Mammographic breast density response to aromatase inhibition.

PURPOSE Mammographic breast density (MBD) is decreased by tamoxifen, but the effect of aromatase inhibitors is less clear. EXPERIMENTAL DESIGN We enrolled early-stage postmenopausal patients with breast cancer initiating adjuvant aromatase inhibitor therapy and ascertained mammograms before and at an average 10 months of aromatase inhibitor therapy. We matched cases to healthy postmenopausal ...

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Association between mammographic breast density and breast cancer tumor characteristics.

OBJECTIVE Few studies have examined the association between breast density and breast cancer tumor characteristics. We examined the association between hormonal, proliferative, and histologic tumor characteristics and mammographic breast density in women with breast cancer. METHODS We conducted a cross-sectional analysis in 546 women diagnosed with invasive breast cancer to evaluate the assoc...

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Racial differences in mammographic breast density.

BACKGROUND African American women have a lower incidence but a higher mortality from breast carcinoma than Caucasians. A proposed explanation for this discrepancy is the decreased efficacy of screening among African American women. Increased breast density in African American women may result in decreased sensitivity of mammography. The purpose of this article is to determine whether there is a...

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ژورنال

عنوان ژورنال: Medical Physics

سال: 2015

ISSN: 0094-2405

DOI: 10.1118/1.4935141